Sunday, 09 June 2019 09:55

How Do Specialized Pro-Resolving Mediators Work?

We’ve discussed specialized pro-resolving mediators (SPMs) quite frequently on this blog, and for good reason! These small molecules play a very important role in the human body, in more than one way. You would be surprised at what additional health benefits they offer. We’ve yet to address a frequently asked question: how do specialized pro-resolving mediators work?

How Do Specialized Pro-Resolving Mediators Work?

Specialized pro-resolving mediators are unique kinds of “cell signalers” that operate in the body. More specifically, SPMs are formed in your cells through the metabolism of polyunsaturated fatty acids (PUFA). They also represent a portion of the Omega-3 fatty acid spectrum.

SPMs, acting as cell signalers, tell our immune system to turn off inflammatory responses before they get out of control and cause damage to our bodies — chronic inflammation can lead to several diseases and conditions. Inflammation is the body’s natural and desirable response to injury and illness. It helps protect the afflicted area.

However, it is possible to have too much of a good thing. Essentially, the main purpose of SPMs is to combat and reduce this inflammation. This anti-inflammatory property works effectively, without compromising your body’s immune response.

The Biochemistry

SPMs are, basically, metabolites of arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) or n-3 DPA. These metabolites are one of the following:

  • Lipoxins

  • Resolvins

  • Protectins

  • Maresins

All of these metabolites have different functions such as nerve protection, cell regeneration, or blocking pain perceptions. They all serve a similar purpose as an anti-inflammatory.

The Specific Process of How SPMs Work

Let’s assume that you experienced a minor injury, such as a cut on your hand. In the tissues that surround that cut, SPMs are produced through the metabolism process mentioned earlier. SPMs begin to function in the tissues surrounding the injury as “resolution agonists.” These resolution agonists target the immune system cells that mediate the inflammatory response. The SPMs bind to specific cellular receptors to modify the cell behavior to reduce inflammation.

This whole process tells the immune system to stop responding to pro-inflammatory signals and, instead, accelerate the return to homeostasis. In the instance of the cut hand, your immune system will respond naturally to the infection by inflaming the area around it. SPMs slow inflammation once the threat is mitigated. They then signal the beginning of the healing process. So, the cut may look and feel inflamed temporarily, but give your body some time and inflammation will go down.

Health Benefits of SPMs

SPMs are not just limited to the treatment of small cuts and bruises. Clinical research studies have shown that SPMs can significantly impact a wide array of pathological inflammation-based conditions, including:

  • Autoimmune diseases

  • Type 1 and type 2 diabetes

  • Metabolic syndrome

  • Dementia syndromes

  • Allergic inflammatory diseases

Aside from these medical conditions, these specialized pro-resolving mediators have been shown to combat heart disease, promote healthy infant births, reduce the risk of cancer, reduce vision loss among older adults, and much more.

The question shouldn’t be “how do specialized pro-resolving mediators work,” but actually, “what can’t those SPMs help fix?”

Do I Need To Supplement Specialized Pro-Resolving Mediators?

SPM Active, a health supplement that aides your immune system responses.

Anyone can naturally increase their intake of specialized pro-resolving mediators by eating a well-balanced diet that includes fish, seeds, and nuts. For some, though, it can be difficult to get the right amount into your diet. If you’re interested in a more direct way of raising your levels of SPM, supplements are the best way to go.

Supplements, like SPM Active, are derived from fish oil (anchovies, sardines, mackerel, etc.) using a patented fractionation process to create a product that is rich in SPMs.

Where Can I Get SPM Active?

Hopefully, we were able to answer the commonly asked question: “how do specialized pro-resolving mediators work?” They offer the average human body incredible health benefits. Thanks to our unique partnership, a high-quality SPM supplement can be easily accessed.

A daily SPM supplement, like SPM Active, may be perfect for your everyday routine. Order your first container of SPM Active today and start living your best life!

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