Specialized Pro-Resolving Mediators (SPMs) Help Protect Patient’s Brains From Alzheimer’s
In the past, many developing drugs were focused on simply clearing away the Beta-Amyloid and Tau plaques from the brains of AD patients, without much regard for how they got there in the first place. This is typical of modern medicine. Once you develop a tumor or infection, come on in and we can get rid of it. The problem with this approach is that once you have a disease, it is very expensive, invasive and sometimes impossible to get rid of. Once researchers realized that once you have AD, no synthetic drug was going to cure it, they started to focus on the mechanisms that actually caused it in the first place. And here’s what they found...
Alzheimer’s Disease is the result of inflammation causing the destruction of brain cells, and defective clearing away of the resulting plaques by the immune system.
SPMs impact on Alzheimer's: The Research
From one of the research studies:
“Defective phagocytosis (clearing away) of amyloid-β (Aβ) and abnormal inflammatory activation of peripheral blood mononuclear cells (PBMCs) are the two key immune pathologies of MCI (Mild Cognitive Impairment) and AD patients. The phagocytosis of Aβ by PBMCs of MCI and AD patients is universally defective and the inflammatory gene transcription is heterogeneously deregulated in comparison to normal subjects. Recent studies have discovered a cornucopia of beneficial anti-inflammatory and pro-resolving effects of the specialized proresolving mediators (SPMs) resolvins, protectins, maresins, and their metabolic precursors. Resolvin D1 and other mediators switch macrophages from an inflammatory to a tissue protective/pro-resolving phenotype and increase phagocytosis of Aβ. In a recent study of AD and MCI patients, nutritional supplementation by omega-3 fatty acids individually increased resolvin D1, improved Aβ phagocytosis, and regulated inflammatory genes toward a physiological state, but only in MCI patients.”
What this indicates is that by taking certain nutritional supplements, we can help prevent or possibly even reverse Alzheimer’s disease if we catch it in the early stages.
Specialized Pro-Resolving Mediators, or SPMs are specialized chemicals that tell cells to end inflammation in the body.
Until now, the only way for the body to produce a therapeutic dose of SPMs was through a series of enzymatic processes after taking up to 10,000 mg of Omega 3 Fatty Acids (PUFAs) a day.
Recently, however, a Healthcare Professional’s Nutrition company called Metagenics invented and patented a process to produce SPMs directly from PUFAs. You can now take a standardized, tested SPM supplement, bypassing the body’s deficient enzymatic pathways to get the most efficient and complete resolution of inflammation naturally.
In an 8 week trial, Metagenics’ SPM Active supplements were shown to decrease inflammatory markers in the blood by 43 percent, and pain by up to 50 percent.
Now, instead to taking a synthetic NSAID drug with it’s corrosive side effects on the body, you can boost your own immune system with a natural substance that the body produces on its own. The only difference here is that you are getting exponentially more of it to supercharge your immune system’s natural resolution of chronic inflammation. This may decrease your risk of developing a myriad of degenerative health conditions, including Alzheimer’s Disease.
Where Can I Get SPMs?
From the food we eat to the water we drink to the polluted air we breathe, there are thousands of assaults on our bodies every day. Our immune system needs help to fight off these toxins, as well as the viruses and bacteria we constantly encounter.
Consider giving your immune system the supercharging it needs with the help of Metagenics SPM Actives.