Saturday, 08 December 2018 19:47

SPMs and Alzheimers

Multiple studies from the National Institutes of Health research website show Specialized Pro-Resolving Mediators can help clear Beta-Amyloid plaques and inflammation in early Alzheimer’s disease, resulting in improved cognitive functioning. Alzheimer’s Disease (AD) research has taken a surprising turn of late. Disillusioned with the failure of many Alzheimer’s drug trials, researchers are now focusing on the immune system as playing a key role in preventing and even reversing the disease if caught in the early stages.

Specialized Pro-Resolving Mediators (SPMs) Help Protect Patient’s Brains From Alzheimer’s

In the past, many developing drugs were focused on simply clearing away the Beta-Amyloid and Tau plaques from the brains of AD patients, without much regard for how they got there in the first place. This is typical of modern medicine. Once you develop a tumor or infection, come on in and we can get rid of it. The problem with this approach is that once you have a disease, it is very expensive, invasive and sometimes impossible to get rid of. Once researchers realized that once you have AD, no synthetic drug was going to cure it, they started to focus on the mechanisms that actually caused it in the first place. And here’s what they found...

Alzheimer’s Disease is the result of inflammation causing the destruction of brain cells, and defective clearing away of the resulting plaques by the immune system.

SPMs impact on Alzheimer's: The Research

From one of the research studies:

“Defective phagocytosis (clearing away) of amyloid-β (Aβ) and abnormal inflammatory activation of peripheral blood mononuclear cells (PBMCs) are the two key immune pathologies of MCI (Mild Cognitive Impairment) and AD patients. The phagocytosis of Aβ by PBMCs of MCI and AD patients is universally defective and the inflammatory gene transcription is heterogeneously deregulated in comparison to normal subjects. Recent studies have discovered a cornucopia of beneficial anti-inflammatory and pro-resolving effects of the specialized proresolving mediators (SPMs) resolvins, protectins, maresins, and their metabolic precursors. Resolvin D1 and other mediators switch macrophages from an inflammatory to a tissue protective/pro-resolving phenotype and increase phagocytosis of Aβ. In a recent study of AD and MCI patients, nutritional supplementation by omega-3 fatty acids individually increased resolvin D1, improved Aβ phagocytosis, and regulated inflammatory genes toward a physiological state, but only in MCI patients.”

Metagenics SPM Active supplement, available through Hope N Wellness.

What this indicates is that by taking certain nutritional supplements, we can help prevent or possibly even reverse Alzheimer’s disease if we catch it in the early stages.

Specialized Pro-Resolving Mediators, or SPMs are specialized chemicals that tell cells to end inflammation in the body.

Until now, the only way for the body to produce a therapeutic dose of SPMs was through a series of enzymatic processes after taking up to 10,000 mg of Omega 3 Fatty Acids (PUFAs) a day.

Recently, however, a Healthcare Professional’s Nutrition company called Metagenics invented and patented a process to produce SPMs directly from PUFAs. You can now take a standardized, tested SPM supplement, bypassing the body’s deficient enzymatic pathways to get the most efficient and complete resolution of inflammation naturally.

In an 8 week trial, Metagenics’ SPM Active supplements were shown to decrease inflammatory markers in the blood by 43 percent, and pain by up to 50 percent.

Now, instead to taking a synthetic NSAID drug with it’s corrosive side effects on the body, you can boost your own immune system with a natural substance that the body produces on its own. The only difference here is that you are getting exponentially more of it to supercharge your immune system’s natural resolution of chronic inflammation. This may decrease your risk of developing a myriad of degenerative health conditions, including Alzheimer’s Disease.

Where Can I Get SPMs?

From the food we eat to the water we drink to the polluted air we breathe, there are thousands of assaults on our bodies every day. Our immune system needs help to fight off these toxins, as well as the viruses and bacteria we constantly encounter.

Consider giving your immune system the supercharging it needs with the help of Metagenics SPM Actives.

Related items

  • Take Control Of Your Wellness With A De-Stress Supplement Take Control Of Your Wellness With A De-Stress Supplement

    Stress is a natural part of life. It’s a biological reaction that helps keep us moving in the right direction. Some days you may feel stress-free, and at other times, your stress can completely consume you. Those intense anxiety-filled days can have a significant negative impact on your mental wellness. It’s important to practice self-care to help reduce your stress, but sometimes, that just isn’t enough. Sometimes the best solution for your mental well-being is an effective de-stress supplement.

  • What Makes Metagenics PhytoMulti Such A Special Multivitamin What Makes Metagenics PhytoMulti Such A Special Multivitamin

    These days there’s an abundance of multivitamins on the market. From gummy vitamins for kids to softgel capsules for adults, multivitamins have become a healthy piece of a well-balanced diet. And while each multivitamin comes with its pros and cons, few options can compare to the specialized nutrition of Metagenics PhytoMulti Capsules. This unique supplement offers a wide range of health benefits thanks to its hyper-targeted formula.

  • How L-Carnitine And Weight Loss Are Connected How L-Carnitine And Weight Loss Are Connected

    If you’re trying to lose weight, then you already know how difficult the journey can be. Successful weight loss can only be achieved when you are consistently in a caloric deficit, which often requires adherence to a healthy balanced diet and a diligent exercise regimen. It sounds easy enough, but it isn’t always that simple for everyone. During your weight loss journey, so many major and minor factors can influence your progress. And one such factor is L-carnitine. Believe it or not, this amino acid derivative can offer tremendous benefits for your weight loss journey. Today we’ll examine the ways L-carnitine and weight loss are connected.

  • Men's Health
  • Aging
Arginine Plus Purchase Item CoQ10 ST-100 Purchase Item Cardiogenics Intensive Care Purchase Item SPM Active Purchase Item Heart disease is the leading cause of death for Americans. In fact, it is estimated that 1 in every 4 deaths in the U.S. is due to
SPM Active Purchase Item   Multiple studies from the National Institutes of Health research website show Specialized Pro-Resolving Mediators can help clear Beta-Amyloid plaques and inflammation in early Alzheimer’s disease, resulting in improved cognitive functioning. Alzheimer’s